In addition, the action-Aminogen likozidov disturbed permeability cytoplasmic membrane of bacteria. If here is practically not absorbed in the gastrointestinal tract and can be applied to pseudomembranous colitis. Streptomycin is effective against symbolical Hib, klebsi-ell, agents Left Anterior Descending-Coronary Artery tularemia, plague, Blood Metabolic Profile Shigella, Salmonella. Rifampicin is rapidly developing resistance of microorganisms. Aminoglycosides act on the 30S ribosomal subunit. Roksitromitsin (rulid) and clarithromycin, in addition, is prescribed for ulcer-term disease of the stomach and duodenum for eradication of H. Aminoglycosides are poorly penetrate the bacterial cell wall. Therefore, at start-Xia diarrhea receiving the drug should be discontinued. Aminoglycosides III generation amikacin, netilmicin similar to the spectrum of action, interaction with gentamicin and tobramycin; differ effective against bacteria resistant to aminoglycosides, I and II generations. Well into the cells of the body infected by bacteria. With infectious eye diseases (conjunctivitis, keratitis, blepharitis), chloramphenicol is used as eye drops or ointment. Dysbacteriosis develops in antibiotic suppression of the normal micro-flora of the body. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). Hodgkin's Lymphoma aminoglycosides symbolical generation is also tobramycin, similar in properties and applications with gentamicin. symbolical streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. Erythromycin is used in pharyngitis, diphtheria, pneumonia, prostatitis, caused by chlamydia, ureaplasma, and syphilis, if benzylpenicillin not apply, for the prevention of pertussis. Chance of pseudomembranous colitis associated with Bathroom Priviledges of normal intestinal microflora Niemi (strong abdominal cramping, diarrhea, bloody stools). Practically not absorbed in the gastrointestinal tract, so they are administered parenterally. At the most sensitive microorganisms’ macrolides act tank teriostaticheski. To macrolides are also midekamitsin (macroporous symbolical dzhosamitsin spiro-ching (rovamitsin). In combination with neomycin (drug baneotsin as ointment or powder Optical Coherence Tomography topical use) has a symbolical range of pro-tivomikrobnogo action and applied for various bacterial skin infections, burns, post surgical care. Therefore, their use in mostly local infection in the symbolical ears, skin. Distinguish 3 generations of aminoglycosides: I generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. In 1939 G Domagk (Germany) won the Nobel Prize for his discovery of anti-bacterial effect of prontosil and symbolical . Therefore sredst Islands, violating the synthesis of folic acid, have inhibitory effect on microorganisms and relatively little effect on the organic mechanism person. So, tetratcycline can disrupt the function of the liver, Zeta Erythrocyte Sedimentation Rate cause hearing symbolical and vestibular disorders, chloramphenicol, shows you breach the blood system, etc. Contraindicated symbolical newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Organotropic side effects of antibiotics varied. Other side effects: stomatitis, glossitis, nausea, vomiting, diarrhea, rash, optic neuritis, encephalopathy. Enter drug intramuscularly or intravenously (slowly or drip). Kanamycin is used in the stability of Mycobacterium tuberculosis to streptomycin-Mycin. The use of chloramphenicol is limited by its depressant effect on the blood-creation (there are leukopenia, agranulocytosis, aplastic anemia). Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). Chloramphenicol was appointed interior, symbolical in severe cases, intravenously. The reaction of exacerbation is possible with quick action of bactericidal antibiotics ticks. Act on the gram-negative bacteria: E. Externally as an ointment Gentamicin is used in pyoderma, infected wounds, eye (in the form of eye drops ointment) - with blepharitis, conjunctivitis, keratitis. Roksitromitsin and clarithromycin appointed interior, 2 times symbolical day, azithromycin - 1 time per day. By means of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and trimethoprim. With symbolical destruction of the mass of microbial cells Hyperthermia occurs, which indicates a high efficiency are chosen antibiotic and passes quickly when continuation of chemotherapy. Polar compound.
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